Nephrotic

Nephrotic syndrome is a common chronic kidney disease in children, with high risk of disease relapses and complications. Management requires home monitoring of urine protein by using urine dipsticks. We plan to design a mobile application (app) that harnesses the portability, accessibility, and ease-of-use of smartphones to assist in the reading of urine protein results. The app will perform colorimetric analysis of urine protein dipstick results using the built-in camera. The app will be developed on the iOS platform. The colorimetric analysis function will be designed for a common commercial urine test strip – Chemstrip 2 GP (Roche). The performance of the colorimetric analysis function will be tested under 3 different light conditions across varying degrees of proteinuria using urine samples collected routinely at a nephrology clinic. Accuracy and precision will be compared to a commercial analyzer (Urisys 1100, Roche) and to visual inspection. Our goal is to develop a useful and valid mobile app for the analysis of urine protein on dipsticks.

PI
Darryl Wright, Wilbur Lam & Chia-shi Wang
Publications

Wang, C., Boyd, R., Mitchell, R., Wright, W.D., McCracken, C., Escoffery, C., Patzer, R., Greenbaum, L., “Development of a Novel Mobile Application to Detect Urine Protein for Nephrotic Syndrome Disease Monitoring”, BMC Med Inform Decis Mak 19, 105 (2019). https://doi.org/10.1186/s12911-019-0822-z

Research Areas