Nanotechnology

Pediatric diseases can be complex, and their treatments must be ultra-safe. To avoid side effects, reduce dosages, and report on outcomes, Georgia Tech researchers create complex but small structures – nanoparticles – that have multiple sophisticated functions in the body, such as engaging the immune system to fight infections, and reporting back on the patient’s condition.  We help define and advance the field of “Pediatric Nanomedicine” and, with it, the creation of revolutionary new treatments.

Funded Projects
 

 Evaluation of Gene-corrected Hematopoietic Stem Cells for Treating Sickle Cell Disease

 PI’s: David Archer 

 

 

 

 Novel Oral Meningococcal Vaccine-Loaded Nanoparticles

 PI's: Susu Zughaier 

 

 

 Nuclease-Based Gene Correction for Treating Spinal Muscular Atrophy

 PI’s: Wilfried Rossol 

 

 

 SERS Assays for RSV and Influenza Detection

 PI’s: Larry Anderson 

 

 Zinc Finger and TAL Nucleases Based Gene Correction for Treating Cystic Fibrosis

 PI’s: Nael McCarty 

 

 

 Laser-Activated Nanoparticles for Targeted Drug Delivery to Retinoblastoma 

 PI’s: Mark Prausnitz 

 

 

 

 Nanotherapy of Inflammatory Bone Disorders in Sickle Cell Disease

 PI’s: Neale Weitzmann 

 

 

 Platelets as Contractile Nanomachines for Targeted Drug Delivery in Hemostasis and Thrombosis

 PI’s: Wilbur Lam 

 

 

 Analysis of Receptor Binding Kinetics and Conformational Change of HIV Envelope Protein

 PI’s: Cheng Zhu 
 

 

 Bacteriophage-Particles to Eliminate Cystic Fibrosis Infections

 PI’s: Andres Garcia 

 

 Correction of a Noval Ryanodine Receptor Mutation Using TALENs

 PI’s: Chunhui Xu & Nael McCarty 

 

 

 Development and Application of a Small Pre-Clinical Animal Model for Juvenile Osteochondritis Dissecans (OCD)

 PI’s: Robert Guldberg 

 

 

 Development of Targeted Outer Membrane Vesicle Nanoparticles for Delivery of Pro-Clotting Factors to the Site of Clot Formation

 PI’s: Anton Bryksin 

 

 

 Engineering Multifunctional Nanoparticles for AML

 PI’s: YongTae Kim, Wilbur Lam, & Jessica Lin 

 

 Functional Gene Delivery via Structural Nucleic Acid Nanotechnology

 PI’s: Yonggang Ke 

 

 

 

 Gene Correction Approaches for Treating Long QT Syndrome in Children

 PI’s: Gang Bao 

 

 Hemodynamics of Neutrophil Trafficking in the CF Pulmonary Vasculature

 PI’s: Wilbur Lam 

 

 

 Identification of Peptide-Based Activators and Inhibitors of the CFTR Protein, for Research or Therapeutic use

 PI’s: Nael McCarty 

 

 

 

 mRNA-Based Therapeutics for the Treatment of hRSV Infections

 PI’s: Philip Santangelo & Tom Barker 

 

 Programmed Immune Response and Avoidance with Virus-Like Nanoparticles, and Click Chemistry Solutions to Line Infections

 PI’s: M.G. Finn 

 

 

 

 RNASeq for Clinical Diagnosis of Neuromuscular Diseases

 PI’s: Greg Gibson & Keiko Tarquinio 

 

 

 The Role Of Force Generation By Target Cells In HIV‐1 Entry And Fusion

 PI’s: Gregory Melikian & Madhuri Hedge